For laboratory research use only. Not for human consumption.
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Illustrative certificateNS-2026-06038Nordicstar Analytical Sciences
TB-500 5 MG
Illustrative certificateNS-2026-06039Nordicstar Analytical Sciences
TB-500 10 MG
Repair & Recovery
Thymosin beta-4 fragment identity & metabolism
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For laboratory research use only.
Not for human consumption or clinical use.
The records shown here are illustrative. Request laboratory-issued documentation for your lot before ordering.
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Shipping information01 / The compound
Thymosin beta-4 fragment identity & metabolism
TB-500 is a synthetic peptide commonly identified as Ac-LKKTETQ, an N-terminally acetylated sequence containing seven amino acids.
The sequence corresponds to residues 17-23 of thymosin beta-4, a naturally occurring 43-amino-acid peptide involved in actin-associated cellular processes.
Because TB-500 contains only a small portion of the parent molecule, research involving full-length thymosin beta-4 should not automatically be treated as evidence for TB-500.
The fragment contains the LKKTET sequence, a region associated with actin interaction in thymosin beta-4 research.
02 / Research profile
Research specifically involving TB-500 or the Ac-LKKTETQ sequence is considerably more limited than research on full-length thymosin beta-4. The most useful direct studies currently include analytical characterization, metabolism research, cell-based experiments, and animal tendon models.
A 2012 analytical study characterized material marketed as TB-500 using chromatographic and high-resolution mass-spectrometry techniques. Researchers identified the material as the N-acetylated thymosin beta-4 17-23 fragment Ac-LKKTETQ. Why it matters: This study is important for establishing the chemical identity associated with the name TB-500, rather than demonstrating a biological outcome.
A 2024 study examined TB-500 and several metabolites using analytical, cellular, and animal models. The research showed that the parent peptide underwent substantial metabolism and identified shorter acetylated metabolites. In a cell-based wound-healing assay, one metabolite, Ac-LKKTE, demonstrated measurable activity. These findings suggest that the biological behavior of administered TB-500 may involve its metabolites as well as the intact seven-amino-acid peptide.
A 2026 preclinical study investigated TB-500, BPC-157, and their combination in a surgically repaired rat Achilles tendon model. At the four-week endpoint, tendons in the TB-500 group demonstrated a significantly greater maximum load to failure than controls in the biomechanical analysis. These findings are limited to an animal model and should not be interpreted as evidence of equivalent effects in humans.
Reading the evidence
Direct TB-500 evidence is substantially narrower than the literature on full-length thymosin beta-4. It includes chemical characterization, metabolism studies, cellular experiments and animal tendon models. The supplied source does not identify established human clinical evidence for the seven-amino-acid fragment.
03 / Reference data
Reference specifications describe a compound. The final lot documentation identifies the material supplied.
| Compound | TB-500 |
|---|---|
| Research area | Repair & Recovery |
| Physical form | Lyophilized |
| Vial options | 5 MG · 10 MG |
| Intended use | Laboratory research only |
Variant amounts are nominal catalog quantities. They are not instructions for use.
HPLC separates components under a defined method. Read the reported percentage alongside the chromatogram, wavelength, integration method, and scope of the test.
Mass spectrometry provides molecular-mass evidence. Identity and chromatographic purity answer different questions; one cannot stand in for the other.
Connect the product name, variant, lot identifier, report date, and issuing laboratory. A report is useful only when its sample can be linked to the material being reviewed.
Every TB-500 lot is analyzed by Nordicstar Analytical Sciences for identity, content, and purity by HPLC with LC-MS confirmation. Each certificate carries a report number and verification key that can be checked at nordicstarlabs.com/verify. Research references below describe published science, not a certificate for a vial.
Read a COA with confidence| Presentation | Lot | HPLC purity | Tested | Certificate |
|---|---|---|---|---|
| 5 MG Current lot | GLZ-26-TB500-1037 | 99.652% | 25 Sep 2026 | NS-2026-06038 |
| 10 MG Current lot | GLZ-26-TB500-1038 | 99.690% | 14 Sep 2026 | NS-2026-06039 |
| 5 MG | GLZ-26-TB500-763 | 99.629% | 12 Aug 2026 | NS-2026-06147 |
| 10 MG | GLZ-26-TB500-762 | 99.553% | 10 Aug 2026 | NS-2026-06149 |
| 5 MG | GLZ-26-TB500-663 | 99.736% | 17 Jul 2026 | NS-2026-06148 |
| 10 MG | GLZ-26-TB500-662 | 99.585% | 12 Jul 2026 | NS-2026-06150 |
05 / Storage & handling
Store TB-500 according to the conditions supplied with the product and applicable laboratory handling procedures. Refer to the lot documentation for product-specific information.
Explore the handling guide06 / Common questions
TB-500 is a synthetic seven-amino-acid peptide commonly identified as Ac-LKKTETQ. It corresponds to residues 17-23 of the larger 43-amino-acid peptide thymosin beta-4.
No. TB-500 is a short fragment derived from the thymosin beta-4 sequence, while thymosin beta-4 is a 43-amino-acid peptide. The two molecules differ in size, molecular weight, chemical identifiers, and the amount of direct research available for each.
The commonly recognized TB-500 sequence is Ac-LKKTETQ, representing an N-acetylated seven-amino-acid fragment of thymosin beta-4.
TB-500 contains seven amino acids and corresponds to residues 17-23 of thymosin beta-4.
LKKTETQ represents the seven amino acids in the peptide sequence. Ac- indicates that the N-terminus of the peptide is acetylated.
Direct TB-500 research includes analytical characterization of Ac-LKKTETQ, metabolism and cell-based studies, and more recent animal research involving tendon-healing models. This evidence should be distinguished from the much larger body of research conducted using full-length thymosin beta-4.
TB-500 and BPC-157 are chemically distinct research peptides with different sequences, origins, and research histories. They have both appeared in preclinical tissue-research literature, including a 2026 rat Achilles tendon study, but evidence involving one peptide should not be attributed to the other.
07 / Further reading
Selected literature for context. Read each study’s methods, experimental model, and limitations alongside its findings.
Curated pairings
