Peptide structure
The linear sequence contains norleucine at position 4 and D-phenylalanine at position 7. These substitutions distinguish afamelanotide from endogenous α-MSH and underpin structure–activity comparisons.
GLPZone / The research collection
Illustrative certificateNS-2026-06060Nordicstar Analytical Sciences
Melanotan-1 10 MG
99.766%HPLC purity
- Lot
- GLZ-26-MT1-1059
- Measured content
- 10.05 mg
- Mass-spec identity
- Confirmed
- Endotoxin
- <1.0 EU/mg
- Tested
- 16 Sep 2026
Healthy Aging
Melanotan-1
Afamelanotide · MC1R & peptide structure research
A pair saves 10%. A set of three saves 15%.
For laboratory research use only.
Not for human consumption or clinical use.
Compound details
- Compound
- Melanotan-1
- CAS number
- 75921-69-6
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.85 g/mol
- Form
- Lyophilized
Quality & documentation
The records shown here are illustrative. Request laboratory-issued documentation for your lot before ordering.
- Lot
- GLZ-26-MT1-1059
- HPLC purity
- 99.766%
- Measured content
- 10.05 mg
- Tested
- 16 Sep 2026
- Report
- NS-2026-06060
Shipping & handling
Priority, tracked shipping within the United States, free on orders of $200 or more after savings. Add Priority dispatch at checkout to have your order packed first; Private Clients receive it on every order. Follow the product documentation for laboratory handling requirements.
Shipping information01 / The compound
Understand
the starting point.
Afamelanotide · MC1R & peptide structure research
Melanotan 1 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). Also known as afamelanotide and NDP-MSH, it is a linear peptide composed of 13 amino-acid residues.
Its structure differs from endogenous α-MSH at two positions: norleucine replaces methionine at position 4, while D-phenylalanine replaces L-phenylalanine at position 7. These substitutions are defining structural features of afamelanotide.
02 / Research profile
The pathways.
The possibilities.
Published research has investigated afamelanotide through the melanocortin receptor system, particularly the melanocortin-1 receptor (MC1R).
MC1R is a G-protein-coupled receptor. Activation by an agonist stimulates adenylyl cyclase and increases intracellular cyclic AMP (cAMP), initiating downstream signaling involved in melanocyte biology and melanin production. Structural research has directly examined afamelanotide bound to MC1R and characterized receptor-ligand interactions within the melanocortin signaling system.
These findings provide structural and mechanistic context for studying Melanotan 1 within controlled laboratory and receptor-model systems.
MC1R recognition
Structural research examines afamelanotide bound to the melanocortin-1 receptor and maps peptide–receptor interactions. Cellular signaling studies connect receptor activation with adenylyl cyclase and intracellular cAMP.
Comparison with Melanotan II
Melanotan I is a linear 13-residue analogue; Melanotan II is a shorter cyclic analogue with a different receptor profile. The two compounds are not interchangeable research identities.
Reading the evidence
The cited findings describe the compound in the experimental systems used. Cellular, biochemical and animal results should be interpreted according to their model, methods and endpoints; they do not establish the performance of a GLPZone lot.
03 / Reference data
The details,
in plain sight.
Reference specifications describe a compound. The final lot documentation identifies the material supplied.
| Compound | Melanotan-1 |
|---|---|
| Research area | Healthy Aging |
| CAS number | 75921-69-6 |
| Molecular formula | C78H111N21O19 |
| Molecular weight | 1646.85 g/mol |
| Physical form | Lyophilized |
| Vial options | 10 MG |
| Intended use | Laboratory research only |
Variant amounts are nominal catalog quantities. They are not instructions for use.
What is in the sample?
HPLC separates components under a defined method. Read the reported percentage alongside the chromatogram, wavelength, integration method, and scope of the test.
Is it the expected compound?
Mass spectrometry provides molecular-mass evidence. Identity and chromatographic purity answer different questions; one cannot stand in for the other.
Does the report match the vial?
Connect the product name, variant, lot identifier, report date, and issuing laboratory. A report is useful only when its sample can be linked to the material being reviewed.
Independent analysis
Every Melanotan-1 lot is analyzed by Nordicstar Analytical Sciences for identity, content, and purity by HPLC with LC-MS confirmation. Each certificate carries a report number and verification key that can be checked at nordicstarlabs.com/verify. Research references below describe published science, not a certificate for a vial.
Read a COA with confidence| Presentation | Lot | HPLC purity | Tested | Certificate |
|---|---|---|---|---|
| 10 MG Current lot | GLZ-26-MT1-1059 | 99.766% | 16 Sep 2026 | NS-2026-06060 |
| 10 MG | GLZ-26-MT1-741 | 99.720% | 15 Aug 2026 | NS-2026-06191 |
| 10 MG | GLZ-26-MT1-641 | 99.613% | 14 Jul 2026 | NS-2026-06192 |
05 / Storage & handling
Care for
the material.
Keep sealed research material protected from moisture, unnecessary light and temperature fluctuations. Use the storage conditions documented for the specific compound, formulation and lot.
Solution stability depends on solvent, concentration, container and experimental conditions. Use a validated laboratory protocol; a universal post-reconstitution shelf life is not established by the literature summaries.
Explore the handling guide06 / Common questions
A little more
understanding.
Are Melanotan I and afamelanotide the same research identity?
Afamelanotide, NDP-MSH and Melanotan I are names associated with the same linear 13-residue α-MSH analogue. A molecular name alone does not establish equivalence between different formulations or supplied lots.
What makes the molecular design distinct?
Norleucine replaces methionine at position 4, and D-phenylalanine replaces L-phenylalanine at position 7. These are defining structural features used in the cited receptor and analogue research.
07 / Further reading
Go to
the source.
Selected literature for context. Read each study’s methods, experimental model, and limitations alongside its findings.
- 01Ma S, et al. Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. Cell Research. 2021. pubmed.ncbi.nlm.nih.gov / Published literature
- 02Hunt G, Donatien PD, Lunec J, Todd C, Kyne S, Thody AJ. Cultured human melanocytes respond to MSH peptides and ACTH. Pigment Cell Research. 1994. PMID: 7855066. pubmed.ncbi.nlm.nih.gov / Published literature
- 03Roberts DW, Newton RA, Leonard JH, Sturm RA. Melanocytes expressing MC1R polymorphisms associated with red hair color have altered MSH-ligand activated pigmentary responses in coculture with keratinocytes. Journal of Cellular Physiology. 2008;215(2):344–355. DOI: 10.1002/jcp.21318. PMID: 17960564. pubmed.ncbi.nlm.nih.gov / Published literature
- 04Compound Reference: Afamelanotide — PubChem / National Library of Medicine. pubchem.ncbi.nlm.nih.gov / Published literature
Curated pairings
