For laboratory research use only. Not for human consumption.
Free U.S. shipping on $200+GLPZone / The research collection
Illustrative certificateNS-2026-06023Nordicstar Analytical Sciences
MOTS-C 10 MG
Illustrative certificateNS-2026-06024Nordicstar Analytical Sciences
MOTS-C 20 MG
Illustrative certificateNS-2026-06025Nordicstar Analytical Sciences
MOTS-C 30 MG
Illustrative certificateNS-2026-06026Nordicstar Analytical Sciences
MOTS-C 40 MG
Metabolic Research
Mitochondrial signaling & cellular adaptation
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For laboratory research use only.
Not for human consumption or clinical use.
The records shown here are illustrative. Request laboratory-issued documentation for your lot before ordering.
Priority, tracked shipping within the United States, free on orders of $200 or more after savings. Add Priority dispatch at checkout to have your order packed first; Private Clients receive it on every order. Follow the product documentation for laboratory handling requirements.
Shipping information01 / The compound
Mitochondrial signaling & cellular adaptation
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within mitochondrial 12S rRNA. Research has examined MOTS-c as part of the signaling network between mitochondrial activity, cellular metabolism, and adaptive stress responses.
Because MOTS-c is encoded by mitochondrial rather than nuclear DNA, it has become an important research model for studying communication between mitochondria and the cell nucleus.
02 / Research profile
Foundational experiments connect MOTS-c with folate-cycle and purine-biosynthesis pathways, AICAR accumulation and AMPK-associated signaling. Stress-related nuclear translocation is a separate research observation linking a mitochondrial-derived peptide to nuclear gene regulation.
The original MOTS-c research identified the peptide within mitochondrial DNA and investigated its relationship with cellular metabolic regulation. Experimental work found connections with the folate cycle, de novo purine biosynthesis, endogenous AICAR levels, and AMPK-associated signaling. Much of the foundational intervention research was conducted in cellular and animal models.
MOTS-c has also been studied as a signaling molecule between mitochondria and the nucleus. Under metabolic stress, researchers observed MOTS-c translocation to the nucleus, where it was associated with changes in stress-responsive nuclear gene expression. This work has made MOTS-c particularly relevant to research into how mitochondrial signals can influence broader cellular responses.
MOTS-c has been investigated in experimental models involving skeletal-muscle biology, metabolic regulation, exercise-associated signaling and age-related physiological changes. Preclinical studies have examined administered MOTS-c in animal models, including changes in metabolic signaling, skeletal-muscle function and physical-capacity measures under controlled experimental conditions. These findings should be interpreted within the specific animal models and experimental systems used.
Reading the evidence
Published MOTS-c research spans cellular experiments and animal models examining mitochondrial signaling, metabolic regulation, cellular stress responses and skeletal-muscle biology. Evidence from different experimental systems should not be treated as interchangeable, and findings should be interpreted according to the specific model, methodology and conditions used in each study.
03 / Reference data
Reference specifications describe a compound. The final lot documentation identifies the material supplied.
| Compound | MOTS-C |
|---|---|
| Research area | Metabolic Research |
| CAS number | 1627580-64-6 |
| Molecular formula | C81H131N21O22S2 |
| Molecular weight | 1820.16 g/mol |
| Physical form | Lyophilized |
| Vial options | 10 MG · 20 MG · 30 MG · 40 MG |
| Intended use | Laboratory research only |
Variant amounts are nominal catalog quantities. They are not instructions for use.
HPLC separates components under a defined method. Read the reported percentage alongside the chromatogram, wavelength, integration method, and scope of the test.
Mass spectrometry provides molecular-mass evidence. Identity and chromatographic purity answer different questions; one cannot stand in for the other.
Connect the product name, variant, lot identifier, report date, and issuing laboratory. A report is useful only when its sample can be linked to the material being reviewed.
Every MOTS-C lot is analyzed by Nordicstar Analytical Sciences for identity, content, and purity by HPLC with LC-MS confirmation. Each certificate carries a report number and verification key that can be checked at nordicstarlabs.com/verify. Research references below describe published science, not a certificate for a vial.
Read a COA with confidence| Presentation | Lot | HPLC purity | Tested | Certificate |
|---|---|---|---|---|
| 10 MG Current lot | GLZ-26-MOTSC-1022 | 99.705% | 25 Sep 2026 | NS-2026-06023 |
| 40 MG Current lot | GLZ-26-MOTSC-1025 | 99.591% | 22 Sep 2026 | NS-2026-06026 |
| 20 MG Current lot | GLZ-26-MOTSC-1023 | 99.736% | 20 Sep 2026 | NS-2026-06024 |
| 30 MG Current lot | GLZ-26-MOTSC-1024 | 99.698% | 19 Sep 2026 | NS-2026-06025 |
| 40 MG | GLZ-26-MOTSC-775 | 99.700% | 18 Aug 2026 | NS-2026-06123 |
| 10 MG | GLZ-26-MOTSC-778 | 99.595% | 17 Aug 2026 | NS-2026-06117 |
| 30 MG | GLZ-26-MOTSC-776 | 99.624% | 16 Aug 2026 | NS-2026-06121 |
| 20 MG | GLZ-26-MOTSC-777 | 99.754% | 15 Aug 2026 | NS-2026-06119 |
| 40 MG | GLZ-26-MOTSC-675 | 99.738% | 15 Jul 2026 | NS-2026-06124 |
| 30 MG | GLZ-26-MOTSC-676 | 99.662% | 13 Jul 2026 | NS-2026-06122 |
| 10 MG | GLZ-26-MOTSC-678 | 99.571% | 12 Jul 2026 | NS-2026-06118 |
| 20 MG | GLZ-26-MOTSC-677 | 99.586% | 11 Jul 2026 | NS-2026-06120 |
05 / Storage & handling
Follow the storage information provided with the product and the laboratory’s validated storage protocol. Keep lot documentation associated with the corresponding research material so testing and identification records remain easy to verify.
Explore the handling guide06 / Common questions
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA. It has been studied in research involving mitochondrial signaling, cellular metabolism, stress responses, skeletal muscle, exercise, and aging.
MOTS-c is encoded within the mitochondrial 12S rRNA region rather than by a nuclear gene. Experimental observations of stress-associated nuclear translocation provide a model for studying communication between mitochondria and nuclear gene regulation.
07 / Further reading
Selected literature for context. Read each study’s methods, experimental model, and limitations alongside its findings.
Curated pairings
